Labetalol HCl 5mg | 20mL Injectable MDV

Labetalol HCl Injectable, manufactured by Hikma Pharmaceuticals under the product code 00409012525, is a potent antihypertensive medication used to manage severe hypertension. Each multidose vial (MDV) contains 5mg of Labetalol Hydrochloride per mL in a 20mL solution, designed for intravenous (IV) administration. Labetalol is a combined alpha and beta-adrenergic receptor blocker, providing rapid blood pressure control in critical care settings.

Key Features:

1. Active Ingredient:
   • Labetalol Hydrochloride: A non-selective beta-adrenergic receptor blocker and selective alpha-1 receptor blocker. This dual mechanism of action helps to lower blood pressure by reducing peripheral vascular resistance without significantly reducing resting heart rate or cardiac output.
2. Formulation:
   • Concentration: Each mL of the solution contains 5mg of Labetalol HCl.
   • Volume: The product is supplied in a 20mL multidose vial, allowing for multiple administrations as per clinical requirements.
3. Indications:
   • Hypertensive Emergencies: Effective for the rapid reduction of blood pressure in life-threatening hypertensive crises.
   • Perioperative Hypertension: Used to manage blood pressure during surgery or in the postoperative period.
   • Acute Hypertension Management: Suitable for patients needing short-term management of severe hypertension when oral therapy is not feasible.
4. Administration:
   • Intravenous Use: Designed for IV administration, allowing for rapid onset of action and precise control over blood pressure.
   • Dosage Flexibility: Can be administered as an IV bolus or continuous infusion, providing flexibility in achieving the desired therapeutic effect.
5. Packaging:
   • Multidose Vial: The 20mL MDV is designed for multiple uses, reducing waste and ensuring cost-effectiveness.
   • Sterile and Preserved: The solution is sterile and contains preservatives to maintain its integrity and efficacy over multiple uses.

Clinical Applications:

• Emergency Medicine: Essential in emergency settings for the rapid control of hypertensive crises.
• Intensive Care Units (ICUs): Utilized in ICUs for patients with acute, severe hypertension requiring close monitoring and quick intervention.
• Surgical Settings: Administered perioperatively to manage sudden spikes in blood pressure during surgery and in the immediate postoperative period.